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KMID : 0370019970110000045
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Chung-Ang Journal of Pharmacal Sciences
1997 Volume.11 No. 0 p.45 ~ p.55
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The Constituents from The Leaves of Acanthopanax senticosus var. koreanus
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Abstract
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Constituents from the leaves of Acanthopanax senticosus var. Koreanus(Araliaceae), a plant origin of Acanthopanax senticosi Cortex which has been used as tonic, stress-relaxing agent, antidiabetes, antirheumatic, etc. in Korean folk medicine were isolated.
The methanolic extracts of dried leaves of Acanthopanax senticosus var. Koreanus was suspended in ether to remove fatty substances. The aqueous fraction was further seperated by Amberlite XAD-2 column employing gradient solvent systems(H_2O, 20, 40, 60, 100% MeOH). By successive column chromatography using sephadex LH-20, ODS and polasil gel. Compound Ⅰ and Cpmpound Ⅱ, were isolated from the 40% MeOH fraction.
Chemical structures of Compound Ⅰ and Ⅱ were identified as chiisanoside, and quercetin-3-β-D-galactopyranoside respectively on the basis of physico-chemical and spectral data of IR, FAB-MS, ^1H-NMR, ^13C-NMR, ^1H-^1H COSY, ^13C-^1H COSY and HMBC(^1H-Derected Multiple-bonded Heteronuclear quantum Coherence spectrum).
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